Why do some proteins accumulate even on protein-resistant surfaces?

Proteins with exposed arginine can selectively accumulate even on protein-resistant coatings, as reported by researchers from Science Tokyo. Through an in-depth analysis of which proteins adhere and how they adhere to various anti-fouling surfaces, the team found that arginine disrupts the protective water layer that normally blocks adsorption. Their results will help scientists develop safer and more effective biocompatible materials for medical devices, such as stents and advanced biosensors.