Three DNA loops prove essential for efficient wing tissue regeneration in fruit flies

After an injury, DNA not only changes its activity but also the way it is organized spatially within the cell nucleus. In this process, certain regions of DNA establish new physical contacts through chromatin loops that act as bridges, bringing together sequences that are far apart in the genome's linear sequence. Now, a study has identified—in an animal model—the formation of these loops as an essential step in tissue regeneration after an injury.