Quality control of proteins in the cellular membrane starts at the ribosome
Scientists at the Center for Molecular Medicine Cologne (CMMC) and the CECAD Cluster of Excellence on Aging Research have demonstrated in a biomedical study that ribosomes, the protein factories of our cells, face an unusually tough challenge when building large, membrane-embedded proteins. When protein synthesis fails, ribosomes recruit quality control factors to eliminate the resulting defective proteins.
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